Tanya Lugani, Manju Nagpal*, Deepinder Singh Malik, Ameya Sharma, Vivek Puri1 and Gitika Arora Dhingra Pages 1 - 14 ( 14 )
Acne is a chronic disease associated with pilosebaceous unit and is affected by Propionibacterium acnes bacteria. Approximately 95% of people worldwide suffer from acne in their life span with a higher prevalence among teenagers (esp. boys). Conventional strategies incorporating antibiotics, steroid, hormones, etc. is recommended orally, systemically or topically, employed for the treatment of acne which shows various side effects (itching, scaling, redness, etc.) and is no more commercially accepted. The literature has been collected using various search engines google scholar, pubmed, science direct etc. The review highlights history of acne, its pathophysiology, developmental factors, various treatment evolutions strategies ranging from conventional to novel approach eradicating the secondary effects with enhanced efficacy and safety profile. We concluded various nanotechnological carriers (liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, microsponges and other nanoscale formulations) which are formulated in last decade for effective treatment of acne. Patent literature and marketed formulations are included in last sections. Encapsulation efficiency of anti-acne drugs in different nanocarriers improves the efficacy as well as minimizes the side effects of drug. These carriers showed better bioavailability as well as better penetration effects even to pilosebaceous unit of the skin. Tolerance can be improved by increasing the concentration of anti-acne drug in the nano-carrier formulation. Conventional treatment strategies for acne had some limitations like scaling, itching, inflammation which can be overcome by nano-formulations which exhibits better efficacy. In present, various nano-technological carriers are working potentially for the treatment of the acne. These nano-formulations are also associated with some limitations like drug entrapment, stability issues but these will be overcome in the upcoming years as long as research is being continued in this area.
Acne vulgaris, liposomes, propionibacterium acnes, topical, systemic, hormones.
Chitkara College of Pharmacy, Chitkara University, Punjab, Chitkara College of Pharmacy, Chitkara University, Punjab, Chitkara College of Pharmacy, Chitkara University, Punjab, Chitkara College of Pharmacy, Chitkara University, Punjab, Chitkara College of Pharmacy, Chitkara University, Punjab, NCRD`S Sterling Institute of Pharmacy, Navi Mumbai