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Loading of Propranolol Hydrochloride on MCF and Sustained Release

Author(s):

Xiao-Dong Li* and Qing-Zhou Zhai   Pages 1 - 10 ( 10 )

Abstract:


Aims: Adsorption conditions of propranolol hydrochloride onto MCF are optimized. Properties of this adsorption system are studied. The sustained release properties of propranolol hydrochloride in the loading system are also researched as well.

Background: In today's society, people's demand for drugs is getting higher and higher. With the development of nanotechnology, it is easier to immobilize drugs into nanomaterials, and it can easily transport drugs in human body. It can control drug release, reduce side effects, improve drug efficacy, and develop drug orientation.

Objective: The purpose of this study was to load propranolol hydrochloride, a drug for the treatment of heart disease and hypertension to the MCF nano-mesoporous material, to prepare a sustained-release preparation and investigates the release law of propranolol hydrochloride in simulated human body fluid.

Method: Nanometer mesoporous MCF (mesocellular foams) silica material was prepared in acidic medium using triblockcopolymer poly(ethylene glycol)-block-poly(propyl glycol)-block-poly(ethylene glycol) as template and tetraethoxysilane as silica source. Propranolol hydrochloride drug was incorporated into the MCF mesoporous material by impregnation method to prepare MCF-propranol hydrochloride host-guest composite material. The loading amount of drug was calculated by spectrophotometry and difference subtraction method.

Results: The loading amount of drug was calculated by spectrophotometry and difference subtraction method to be 385.5 mg·g -1 (propranolol hydrochloride/MCF). Adsorption process of propranolol hydrochloride in MCF belongs to the quasi-second-order kinetic process. Adsorption process ΔH 0 = -19.11 kJ·mol-1 , is an exothermic process, ΔG 0 < 0, the adsorption process is a spontaneous process. The effective release time of drug lasted up to 32 h and the maximum cumulative released amount was 99.4 % through the experiment of drug sustained release in the simulated body fluid. In the simulated gastric juice, the release time of drug reached 6 h, the maximum cumulative released amount was 56.6 %. When drug release time arrived at 10 h in the simulated intestinal fluid, the maximum cumulative released amount was 71.3 %.

Conclusions: The influence of the release rate of propranolol hydrochloride molecules from MCF mesopores was demonstrated, since it results in a very slowly drug delivery from the nanocomposite system. Thus, it is illustrated that the prepared MCF is a nice drug sustained-released carrier.

Keywords:

Propranolol hydrochloride, nanometer mesoporous MCF, Sustained release, simulated body fluid, simulated gastric juice, simulated intestinal fluid.

Affiliation:

Department of Basic Science, Jilin Jianzhu University, 5088 Xincheng Street, Changchun 130118, Research Center for Nanotechnology, Changchun University of Science and Technology, Changchun 130022, 7186 Weixing Road



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